Drug intelligence / Profile preview

dextran + glucose + sodium chloride

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Intravenous
01

Overview

Dextran glucose + sodium chloride is an intravenous combination therapy used for fluid resuscitation and plasma volume expansion in patients with sepsis and septic shock. The solution contains dextran, a complex branched polysaccharide that functions as a colloid to increase plasma oncotic pressure, thereby drawing fluid into the intravascular space and improving microcirculatory blood flow. Glucose (dextrose) is included to provide essential metabolic energy during acute stress, while sodium chloride maintains electrolyte balance and tonicity. This combination is typically administered to stabilize hemodynamic parameters, including cardiac index, mean arterial pressure, and central venous pressure, in critically ill patients.

Brand names
RheomacrodexGentranLMD
Other names
Dextran in Dextrose and SalineDextran 40 in 5% Dextrose and 0.9% Sodium ChlorideDextran 70 in 5% Dextrose and 0.9% Sodium Chloride

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