Drug intelligence / Profile preview

dextromethorphan + guaifenesin + phenylephrine

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

dextromethorphan + guaifenesin + phenylephrine is a fixed-dose combination of three active ingredients used for the relief of symptoms associated with cold and respiratory infections. Dextromethorphan is an antitussive that suppresses the cough reflex by acting on the brain to decrease activity in the cough center[1][2]. Guaifenesin is an expectorant that helps loosen and thin mucus in the airways, making it easier to clear phlegm[3]. Phenylephrine is a decongestant that acts as a selective alpha-1 adrenergic receptor agonist, narrowing blood vessels in the nasal passages to reduce congestion[3]. This combination is indicated for temporary relief of cough due to minor throat and bronchial irritation, nasal congestion, and to help with mucus clearance[3].

Brand names
Mucinex Fast-Max Severe Congestion and CoughChildren's Mucinex Multi-Symptom ColdChildren's Robitussin Cough and Cold CFRobitussin Cough and Cold CFSudafed PE Cold/Cough
02

Targets

ADRA1A (α1A)SMPD1 (Acid sphingomyelinase)NMDAR (Glutamate receptor ionotropic, NMDA)SERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)σR (Sigma receptors)

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