dextromethorphan + memantine

Dextromethorphan + memantine is a combination of two NMDA receptor antagonists. Dextromethorphan is commonly used as an antitussive (cough suppressant), while memantine is primarily used to treat moderate to severe dementia related to Alzheimer's disease. Both drugs work by blocking the NMDA receptor in the brain, though potentially with different binding profiles or affinities. This combination has been studied for various neuropsychiatric and neurological conditions, including bipolar spectrum disorder and pain management, where it may provide anti-inflammatory effects and increase neurotrophic factors like BDNF (brain-derived neurotrophic factor). The combination has also been investigated for potential use in amphetamine-type stimulants use disorder.