Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
dextromethorphan + quinidine
- Development stage
- Approved
- Lead developer
- Otsuka Holdings
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Dextromethorphan + quinidine** is an oral fixed-dose small-molecule combination marketed as **Nuedexta** for the treatment of pseudobulbar affect. Dextromethorphan is an uncompetitive N-methyl-D-aspartate receptor antagonist and sigma-1 receptor agonist, while low-dose quinidine inhibits cytochrome P450 2D6 to reduce dextromethorphan metabolism and sustain therapeutic dextromethorphan exposure. The U.S. product contains dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg per capsule. It was developed by Avanir and subsequently integrated into Otsuka's U.S. pharmaceutical business. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=484e0918-3442-49dc-8ccf-177f1f3ee9f3))
- Brand names
- Nuedexta
- Other names
- DM/QDMQNeurodexZenviadextromethorphan + quinidinedextromethorphan and quinidinedextromethorphan hydrobromide + quinidine sulfatedextromethorphan/quinidine
02
Targets
SERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)Nicotinic Acetylcholine ReceptorNMDAR (Glutamate receptor ionotropic, NMDA)NET (Norepinephrine Transporter)
Beyond the preview
Go deeper on dextromethorphan + quinidine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on dextromethorphan + quinidine.