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dextrose + icodextrin + amino acids
- Development stage
- Unknown
- Lead developer
- Sequana Medical
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
Peritoneal dialysis (PD) involves the use of various solutions to facilitate the removal of waste products and excess fluid from the blood when the kidneys are no longer functioning adequately. This specific combination refers to a clinical regimen utilizing three distinct types of PD solutions: **dextrose-based solutions** (e.g., Dianeal), which use glucose as an osmotic agent for fluid removal; **icodextrin-based solutions** (e.g., Extraneal), which contain a glucose polymer that provides sustained ultrafiltration during long-dwell periods (such as overnight) via colloid osmosis; and **amino acid-based solutions** (e.g., Nutrineal), which replace dextrose with amino acids to provide both an osmotic gradient and nutritional support. This multi-solution approach is designed to optimize fluid balance and nutritional status in patients with end-stage renal disease (ESRD) while helping to mitigate the protein loss and glucose-related metabolic issues (like hyperglycemia and weight gain) associated with standard PD.
- Brand names
- DianealNutrineal
- Other names
- glucose + icodextrin + amino acidsdextrose solution + icodextrin + amino acid solution
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