Drug intelligence / Profile preview

dextrose monohydrate + magnesium chloride + sodium lactate + calcium chloride + sodium chloride

Development stage
Approved
Lead developer
Vanttive
Modality
Small Molecules
Administration
Intraperitoneal
01

Overview

Dextrose monohydrate + magnesium chloride + sodium lactate + calcium chloride + sodium chloride is a **peritoneal dialysis solution** marketed as **DIANEAL PD-2 with Dextrose** by Vantive US Healthcare for intraperitoneal use in continuous ambulatory peritoneal dialysis and automated peritoneal dialysis. It is a hypertonic, pharmacologically inactive multicomponent small-molecule solution in which **dextrose** acts as the principal osmotic agent, generating an osmotic gradient across the peritoneal membrane to promote transcapillary ultrafiltration and removal of water and solutes, while **sodium, calcium, magnesium, chloride, and lactate** provide electrolyte and buffer support. The product is indicated for management of **acute kidney injury** and **chronic kidney disease** requiring peritoneal dialysis, and notable risks described for this product class include **peritonitis** and **encapsulating peritoneal sclerosis**; it is contraindicated in severe lactic acidosis.

Brand names
DIANEAL PD-2 with Dextrose
Other names
dextrose monohydrate + magnesium chloride + sodium lactate + calcium chloride + sodium chlorideDIANEAL peritoneal dialysis solutiondianeal pd-2 with dextrose

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