dezocine + midazolam

Dezocine + midazolam is a combination of two pharmaceutical agents used primarily for procedural sedation and analgesia, especially in gastrointestinal endoscopy. Dezocine is an opioid analgesic with mixed agonist/antagonist activity at opioid receptors (μ-agonist, κ-antagonist), providing effective pain relief with a relatively low risk of addiction. Midazolam is a benzodiazepine that acts as a positive allosteric modulator at the GABA-A receptor, producing sedative, anxiolytic, amnestic, and muscle relaxant effects but limited intrinsic analgesia. When combined, these drugs offer both sedation (from midazolam) and analgesia (from dezocine), resulting in improved patient comfort during procedures compared to either agent alone or standard endoscopy without sedation.[1][2][6][10] This combination has been shown to be safe and effective for moderate procedural sedation in adults undergoing colonoscopy or other digestive endoscopic procedures.

Other names

dezocine and midazolammidazolam and dezocine