Drug intelligence / Profile preview

Diane-35 + orlistat

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Diane-35 + orlistat is a non-standard, unbranded combination of two pharmaceutical agents used for distinct indications. Diane-35 is a combined oral contraceptive containing cyproterone acetate (an anti-androgen and progestogen) and ethinylestradiol (an estrogen), primarily indicated for the treatment of androgenization symptoms in women such as moderate to severe acne, hirsutism, and as an oral contraceptive[3][6]. Orlistat is a peripherally acting antiobesity agent that inhibits gastrointestinal lipases, reducing dietary fat absorption to aid weight loss in overweight or obese individuals[1][2][7]. The combination may be considered in clinical scenarios such as polycystic ovary syndrome (PCOS), where both weight management and hormonal regulation are therapeutic goals[4]. However, this specific combination does not exist as a single marketed product; it refers to the concurrent use of both drugs.

02

Targets

ESR1 (ERα)PR (Progesterone receptor)PNLIP (Pancreatic triacylglycerol lipase)AR (Adrenergic receptors)

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