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diazepam + indomethacin (Gramón Bagó)
- Development stage
- Unknown
- Lead developer
- Gramón Bagó
- Modality
- Small Molecules
- Administration
- Oral, Rectal
01
Overview
Artrilona is a fixed-dose combination of the non-steroidal anti-inflammatory drug (NSAID) indomethacin and the benzodiazepine diazepam. Developed and marketed by Gramón Bagó, it is indicated for the treatment of inflammatory and degenerative rheumatic diseases, acute musculoskeletal disorders, post-surgical inflammation, and acute gout. Indomethacin acts as a potent inhibitor of cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis to provide anti-inflammatory, analgesic, and antipyretic effects. Diazepam acts as a positive allosteric modulator of the GABAA receptor, providing muscle relaxant and mild anxiolytic effects to alleviate muscle spasms and pain-associated anxiety.
- Brand names
- Artrilona
- Other names
- diazepam + indometacinaindometacina + diazepamindomethacin + diazepam
02
Targets
BZD site (GABA-A receptor benzodiazepine site)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GABAA (Gamma-aminobutyric acid receptor)
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