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diclofenac + methadone
- Development stage
- Unknown
- Lead developer
- Aalborg University Hospital
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Diclometh is an investigational topical gel formulation combining the non-steroidal anti-inflammatory drug (NSAID) diclofenac and the opioid receptor agonist methadone. Developed by Mech-Sense at Aalborg University Hospital, it is designed to provide local analgesia for neuropathic pain while minimizing systemic side effects. Diclofenac acts by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis, while methadone acts as an agonist at mu-opioid receptors and an antagonist at NMDA receptors. The combination has been evaluated in Phase 2 clinical trials using human experimental pain models (capsaicin- and NGF-induced pain) to assess its efficacy, safety, and systemic absorption.
- Brand names
- Diclometh
- Other names
- diclofenac and methadone gel
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NMDAR (Glutamate receptor ionotropic, NMDA)PGHS-1 (Prostaglandin G/H Synthase 1)MOR (Mu opioid receptor)
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