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This combination therapy, developed by researchers at the Shandong Eye Institute and Qingdao Eye Hospital, is being investigated for the treatment and prevention of myopia progression. Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) that acts as a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2). In the context of myopia, COX-2 inhibition is hypothesized to suppress scleral remodeling and axial elongation by modulating the expression of matrix metalloproteinases and collagen. Vitamin C (ascorbic acid) is included as an antioxidant and a cofactor for collagen synthesis, potentially enhancing the structural integrity of the sclera and reducing oxidative stress associated with myopic changes. The treatment is typically administered as an ophthalmic solution.
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