Drug intelligence / Profile preview

diclofenac + vitamin c

Development stage
Unknown
Lead developer
Shandong Eye Institute
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

This combination therapy, developed by researchers at the Shandong Eye Institute and Qingdao Eye Hospital, is being investigated for the treatment and prevention of myopia progression. Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) that acts as a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2). In the context of myopia, COX-2 inhibition is hypothesized to suppress scleral remodeling and axial elongation by modulating the expression of matrix metalloproteinases and collagen. Vitamin C (ascorbic acid) is included as an antioxidant and a cofactor for collagen synthesis, potentially enhancing the structural integrity of the sclera and reducing oxidative stress associated with myopic changes. The treatment is typically administered as an ophthalmic solution.

Other names
diclofenac sodium + ascorbic aciddiclofenac + ascorbic acid
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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