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diclofenac potassium + dinoprostone
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Vaginal, Oral
01
Overview
A combination of diclofenac potassium, a nonsteroidal anti-inflammatory drug (NSAID), and dinoprostone, a prostaglandin E2. This combination is used for pain management during medical procedures, particularly hysterosalpingography (HSG) in infertile patients. Diclofenac potassium provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase enzymes, while dinoprostone facilitates cervical ripening and softening.
- Other names
- dinoprostone + diclofenac potassiumprostaglandin E2 + diclofenac potassium
02
Targets
PTGER4 (Prostaglandin E2 receptor EP4 subtype)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PTGER1 (Prostaglandin E Receptor 1)PTGER2 (Prostaglandin E2 receptor EP2)PTGER3 (Prostaglandin E2 receptor EP3 subtype)PGHS-1 (Prostaglandin G/H Synthase 1)
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