Drug intelligence / Profile preview

diclofenac potassium + metaxalone

Development stage
Unknown
Lead developer
Sanrey Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

Metapain D is a fixed-dose combination tablet developed and marketed by Sanrey Therapeutics for the management of acute musculoskeletal pain and discomfort associated with muscle spasms. It combines diclofenac potassium, a nonsteroidal anti-inflammatory drug (NSAID), with metaxalone, a centrally acting skeletal muscle relaxant. Diclofenac potassium provides rapid-onset analgesic and anti-inflammatory effects by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, thereby blocking prostaglandin synthesis. Metaxalone acts on the central nervous system to alleviate muscle stiffness and spasms, improving overall mobility. This dual-action formulation is typically used as an adjunct to rest and physical therapy in orthopedic and pain management settings.

Brand names
Metapain DMetapain-D
Other names
diclofenac and metaxalonediclofenac potassium and metaxalonemetaxalone and diclofenacmetaxalone and diclofenac potassium
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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