Drug intelligence / Profile preview

diethylcarbamazine + albendazole

Development stage
Unknown
Lead developer
World Health Organization
Modality
Small Molecules
Administration
Oral
01

Overview

A two-drug combination used primarily for the treatment of lymphatic filariasis. Diethylcarbamazine (DEC) acts as a microfilaricidal agent targeting the larval stage of the parasite, while albendazole is a broad-spectrum antihelmintic that disrupts the parasite's metabolism and microtubules. This combination is recommended by the World Health Organization's Global Programme to Eliminate Lymphatic Filariasis for mass drug administration in endemic areas.

Other names
DEC + albendazole
02

Targets

ALOX5 (Arachidonate 5-lipoxygenase)TUBB (Tubulin (alpha and beta subunits))

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