Drug intelligence / Profile preview

diflucortolone valerate + isoconazole nitrate

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Topical
01

Overview

A topical medication combining diflucortolone valerate (0.1%), a potent fluorinated corticosteroid, with isoconazole nitrate (1%), a broad-spectrum antimycotic azole. This combination is used for treating superficial fungal infections of the skin accompanied by inflammatory or eczematous conditions. Diflucortolone valerate provides anti-inflammatory, antipruritic, and vasoconstrictive effects, while isoconazole nitrate offers antimycotic activity against dermatophytes, yeasts, yeast-like fungi, molds, and gram-positive bacteria.

Brand names
Travocort
Other names
isoconazole nitrate + diflucortolone valerate
02

Targets

GR (Glucocorticoid receptor)PLA2 (Phospholipase A2 group IID)CYP51A1 (Sterol 14α-demethylase)

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