digoxin + K-877

digoxin + K-877 is a **combination formulation** composed of digoxin—a cardiac glycoside that inhibits sodium-potassium ATPase to increase intracellular calcium, resulting in positive inotropic effects and used for heart failure and atrial fibrillation—and K-877 (pemafibrate), a selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα), which is used for dyslipidemia and specifically activates PPARα to modulate lipid and carbohydrate metabolism[3][5][6][8]. Both drugs are small molecules, with digoxin acting on cardiac tissues and K-877 modulating gene transcription relevant to lipid metabolism. Clinical investigations have examined pharmacokinetic interactions between K-877 and digoxin[7].

Brand names

Parmodia

Other names

pemafibrate