Drug intelligence / Profile preview

dihydrocapsiate + capsicum annuum fruit extract + citrus peel extract + coleus forskohlii root extract + irvingia gabonensis seed extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a **combination product** containing five different botanical extracts: dihydrocapsiate (a capsinoid found in non-pungent chili peppers), capsicum annuum fruit extract (source of capsaicinoids and other bioactives), citrus peel extract (source of various flavonoids), coleus forskohlii root extract (source of forskolin), and irvingia gabonensis seed extract (African mango seed extract). The combination is typically marketed as a **weight management dietary supplement**. Mechanisms attributed to its ingredients include sympathetic nervous system stimulation (via capsinoids), thermogenesis, fat oxidation, vasodilation, appetite modulation, and anti-inflammatory/antioxidant effects. There is no strong, high-quality clinical evidence supporting efficacy for weight loss or obesity beyond the established activities of some isolated ingredients.

02

Targets

AC (Adenylyl cyclase family)15-LOX (Lysyl Oxidase)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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