dihydrocodeine tartrate + dl-methylephedrine hydrochloride + chlorpheniramine maleate

A **combination drug** containing dihydrocodeine tartrate (an opioid analgesic and antitussive), dl-methylephedrine hydrochloride (a sympathomimetic bronchodilator), and chlorpheniramine maleate (a first-generation antihistamine)[1][3][6]. - **Mechanism of action**: - Dihydrocodeine acts on the mu-opioid receptor as an agonist, suppressing cough and providing analgesia[5]. - dl-Methylephedrine stimulates adrenergic receptors, relaxing airway smooth muscle to facilitate bronchodilation. - Chlorpheniramine acts as an antagonist at the histamine H1 receptor, reducing allergic symptoms and cough reflex[1][2]. - It is used primarily as an **antitussive** for symptomatic relief of cough related to acute and chronic respiratory diseases, including acute bronchitis, chronic bronchitis, cold/upper respiratory inflammation, pneumonia, and pulmonary tuberculosis[1][4][6]. - This product is approved and marketed in Japan and other countries as a **cough suppressant and cold remedy**[1][4][6].

Brand names

Lightgen Combination SyrupHuscode Combination TabletsCHLOPHEDRIN SCodaewon Forte Syr.

Other names

dihydrocodeine phosphate + dl-methylephedrine hydrochloride + chlorpheniramine maleate