Drug intelligence / Profile preview

diltiazem + fusidic acid

Development stage
Unknown
Lead developer
Alaa Nadhim Hameed
Modality
Small Molecules
Administration
Topical
01

Overview

A topical combination regimen consisting of diltiazem, a benzothiazepine calcium channel blocker, and fusidic acid, a steroid-like antibiotic. Diltiazem is used topically to promote local vasodilation and reduce muscle tone, which can enhance blood flow to wounded tissue and accelerate healing. Fusidic acid provides broad-spectrum antibacterial activity, particularly against Gram-positive organisms like *Staphylococcus aureus*, to prevent surgical site infections. This specific combination is being investigated for its efficacy in improving episiotomy healing, reducing pain, and preventing infection following childbirth.

Other names
topical diltiazem plus fusidic acid
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)EF-G (Elongation factor G 1, mitochondrial)

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