dimeticone + nerolidol

Dimeticone + nerolidol (branded as Hedrin Once Liquid Gel) is a topical combination formulation used for the treatment of head lice infestation (pediculosis capitis). Developed by Thornton & Ross, it consists of 4% dimeticone, a silicone oil, and nerolidol (Penetrol), a naturally occurring linear sesquiterpene alcohol. The mechanism of action is physical rather than neurotoxic; dimeticone acts by coating and suffocating the lice and their eggs, while nerolidol acts as a penetration enhancer and surface tension modifier to facilitate the entry of dimeticone into the breathing apparatus (spiracles) of the lice and the eggs. It is classified as a certified medical device in many jurisdictions due to its physical mode of action.

Brand names

Hedrin Once Liquid GelHedrin OncePenetrol

Other names

dimeticone + nerolidoldimethicone + nerolidol4% dimeticone + nerolidol