Drug intelligence / Profile preview

dimetindene (Novartis)

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Topical
01

Overview

Betiden is a topical gel formulation of dimetindene (as dimetindene maleate), a first-generation selective histamine H1 receptor antagonist with antipruritic and antiallergic properties. Originally developed by Ciba (now Novartis) and marketed locally by Farmavita, dimetindene competitively binds to H1 receptors, preventing histamine-mediated effects such as vasodilation, increased capillary permeability, and sensory nerve stimulation. This action rapidly alleviates itching, redness, and swelling. Betiden is approved for the short-term relief of pruritus associated with dermatoses, urticaria, insect bites, sunburn, and superficial first-degree burns.

Brand names
BetidenDermacutanFeniallergFenistilForestalForhistalForistalGrivix
Other names
dimethindenedimethindene maleatedimethpyrindenedimetindenedimetindene maleate
02

Targets

HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)CHRM2 (M2)CHRM4 (M4)CHRM3 (M3)

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