diphenhydramine + acetaminophen

Diphenhydramine + acetaminophen is an oral combination drug containing two active ingredients: - **Acetaminophen** is a non-opioid analgesic and antipyretic that reduces fever and relieves mild to moderate pain by inhibiting prostaglandin synthesis in the central nervous system. - **Diphenhydramine** is a first-generation antihistamine that acts as an antagonist at histamine H1 receptors. It provides relief from allergy symptoms and also has sedative properties due to its ability to cross the blood-brain barrier. This combination is primarily used for short-term management of occasional insomnia associated with minor aches and pains (such as headache, back pain, joint or muscle pain), as well as for relief of cold or allergy symptoms like runny nose or sneezing when accompanied by discomfort. It should not be used solely for sleep problems without pain[1][2][3][5].

Brand names

Tylenol PMMidol PMPercogesic Original StrengthLegatrin PMHeadache Relief PMTheraflu Multi-Symptom Severe ColdTylenol Cold NighttimeTylenol PM Extra StrengthTylenol Sore Throat Nighttime

Other names

acetaminophen and diphenhydramine