Drug intelligence / Profile preview

diphtheria, tetanus, pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed)

Development stage
Approved
Lead developer
Sanofi
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This drug is a combination vaccine (DTaP-IPV) designed to provide active immunization against diphtheria, tetanus, pertussis (whooping cough), and poliomyelitis. It contains toxoids of diphtheria and tetanus, acellular components of *Bordetella pertussis* (typically pertussis toxoid and filamentous hemagglutinin), and inactivated poliovirus types 1, 2, and 3 (Mahoney, MEF-1, and Saukett strains). The vaccine works by inducing the production of specific antibodies against the toxins produced by *Corynebacterium diphtheriae* and *Clostridium tetani*, the antigens of *Bordetella pertussis*, and the three types of poliovirus, thereby providing protection against the respective diseases. It is primarily used for primary vaccination in infants and as a booster dose in young children and pregnant women.

Brand names
TetravacInfanrix-IPVKinrixQuadracel
Other names
DTaP-IPV4-in-1 vaccineneloisrokotediphtheria toxoid + tetanus toxoid + acellular pertussis vaccine + inactivated poliovirus vaccine
02

Targets

FIM2/FIM3 (Fimbriae types 2 and 3)FHA (Filamentous hemagglutinin)PRN (Pertactin)TT (Tetanus toxoid)

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