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diphtheria + tetanus + acellular pertussis vaccine, adsorbed
- Development stage
- Unknown
- Lead developer
- Changchun BCHT Biotechnology
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A combination vaccine developed by Changchun BCHT Biotechnology for the prevention of diphtheria, tetanus, and pertussis. It utilizes acellular pertussis components (purified antigens) rather than whole-cell bacteria to minimize reactogenicity. The vaccine is adsorbed onto an aluminum-based adjuvant to enhance immunogenicity. BCHT's formulation is specifically a component-based acellular vaccine, which allows for precise control over the concentration of individual pertussis antigens like pertussis toxoid (PT) and filamentous hemagglutinin (FHA), potentially offering better consistency and efficacy than older co-purified acellular vaccines. The vaccine is currently in Phase 3 clinical trials in China.
- Other names
- DTaP vaccineDTPa vaccineAdsorbed Diphtheria, Tetanus and Acellular Pertussis Combined VaccineComponent DTaP
02
Targets
FHA (Filamentous hemagglutinin)PRN (Pertactin)Diphtheria toxinFIM2/FIM3 (Bordetella pertussis fimbriae 2/3)
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