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dipyridamole + aspirin
- Development stage
- Approved
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Dipyridamole + aspirin** is an oral fixed-dose antiplatelet combination, most widely marketed as Aggrenox. Each capsule contains extended-release dipyridamole 200 mg plus immediate-release aspirin 25 mg. Aspirin irreversibly inhibits platelet cyclooxygenase-1, suppressing thromboxane A2 production, while dipyridamole inhibits adenosine uptake and cyclic-nucleotide phosphodiesterase activity, increasing extracellular adenosine and platelet cyclic nucleotide signaling to reduce platelet activation and aggregation. It is approved for secondary prevention of stroke in patients with a prior transient ischemic attack or completed ischemic stroke due to thrombosis. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f07c8535-f9fb-4697-9b63-1ab22210efc9))
- Brand names
- AggrenoxAsasantinAsasantin Retard
- Other names
- acetylsalicylic acid + dipyridamoleacetylsalicylic acid/dipyridamoleaspirin + dipyridamoleaspirin + extended-release dipyridamoleaspirin/dipyridamoleaspirin/extended-release dipyridamoledipyridamole + acetylsalicylic acidextended-release dipyridamole + aspirin
02
Targets
ENT1 (Solute carrier family 29 member 1)PDE5 (Phosphodiesterase 5A)PGHS-1 (Prostaglandin G/H Synthase 1)
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