dipyrone + isometheptene + caffeine

This is a fixed-dose combination drug composed of dipyrone (also known as metamizole), isometheptene, and caffeine, commonly used for the acute treatment of mild-to-moderate primary headache disorders, including tension-type headache and migraine. **Dipyrone** is a potent non-opioid analgesic and antipyretic that works by inhibiting prostaglandin synthesis, leading to reduced pain and fever. **Isometheptene** is a sympathomimetic amine that acts as a cranial vasoconstrictor, attributed to its activation of alpha-adrenergic receptors, thereby reducing dilation of cerebral vessels and potentially alleviating headache. **Caffeine** enhances the vasoconstrictive effect and also provides mild analgesic adjuvant properties via adenosine receptor antagonism. The combination is designed to provide synergistic pain relief through these complementary mechanisms. Multiple randomized studies have shown efficacy and excellent tolerability for acute headache episodes[1][2][3].

Brand names

Neosaldina

Other names

dipyrone + isometheptene + caffeine