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disulfiram + lomustine
- Development stage
- Discontinued
- Lead developer
- NextSource Biotechnology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of disulfiram and lomustine that has been investigated for the treatment of glioblastoma. Lomustine is an alkylating agent that interferes with cancer cell growth by disrupting DNA, while disulfiram is primarily used to treat alcohol addiction but has been studied for potential anticancer properties. The combination was investigated based on preclinical evidence suggesting synergistic effects, particularly when disulfiram is combined with copper supplementation.
02
Targets
DNAALDH1A1 (Aldehyde dehydrogenase 1 family member A1)LY96 (Myeloid differentiation factor 2)
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