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divalproex + phenytoin
- Development stage
- Unknown
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination of two anticonvulsant medications that interact significantly when used together. Divalproex sodium (valproic acid) can displace phenytoin from plasma protein binding sites, increasing free phenytoin levels while potentially inhibiting its metabolism. This interaction can lead to phenytoin toxicity despite normal total phenytoin levels, requiring careful monitoring and potential dosage adjustments.
02
Targets
NaV (Voltage-gated sodium channels)NMDAR (Glutamate receptor ionotropic, NMDA)ABAT (4-aminobutyrate aminotransferase)
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