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Drug intelligence / Profile preview
dmLT (Tulane University)
- Development stage
- Unknown
- Lead developer
- PATH
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intradermal, Intramuscular, Oral, Sublingual
01
Overview
**dmLT** is a recombinant detoxified *enterotoxigenic Escherichia coli* heat-labile enterotoxin protein toxoid carrying the A-subunit mutations R192G and L211A. It is an AB5 mucosal vaccine adjuvant designed to retain the immune-enhancing properties of native heat-labile toxin while substantially reducing enterotoxicity. In PATH's completed Phase 1 polio study, dmLT was co-administered intramuscularly with inactivated poliovirus vaccine to assess whether it could improve systemic and intestinal mucosal immunity and reduce poliovirus shedding after bivalent oral poliovirus vaccine challenge. dmLT is not an approved standalone product. ([journals.asm.org](https://journals.asm.org/doi/10.1128/msphere.00215-18))
- Other names
- dmLTDouble-mutant heat-labile toxinE. coli double-mutant heat-labile toxinLT (R192G/L211A)LT(R192G/L211A)
02
Targets
GM1 (GM1 ganglioside)GNAS
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