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docetaxel + celecoxib
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination therapy consisting of docetaxel, a taxane chemotherapy agent, and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor. Preclinical studies suggested that celecoxib has antitumor activity and can enhance the efficacy of chemotherapy drugs, particularly taxanes. This combination has been investigated in clinical trials for various cancer types, especially non-small cell lung cancer (NSCLC).
- Other names
- celecoxib and docetaxeldocetaxel plus celecoxib
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TUBB (Tubulin (alpha and beta subunits))
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