Drug intelligence / Profile preview

docetaxel + mitoxantrone

Development stage
Phase 3
Lead developer
Sanofi
Modality
Small Molecules
Administration
Intravenous
01

Overview

A chemotherapy regimen consisting of docetaxel and mitoxantrone, primarily studied in sequential rather than simultaneous administration for hormone-refractory prostate cancer (HRPC). Docetaxel is a taxoid that has demonstrated superior survival outcomes compared to mitoxantrone when used as first-line therapy. When used sequentially, patients receiving docetaxel first-line followed by mitoxantrone showed better survival outcomes than the reverse sequence.

Other names
mitoxantrone hydrochloridedocetaxel
02

Targets

DNATOP2B (DNA topoisomerase II beta)TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))

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