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docetaxel + nintedanib
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Docetaxel + nintedanib is a combination therapy used for the treatment of advanced non-small cell lung cancer (NSCLC) of adenocarcinoma histology after failure of first-line chemotherapy. Docetaxel is a cytostatic drug, while nintedanib is a triple angiokinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR) pathways. This combination blocks proteins that regulate the growth and division of cancer cells, effectively slowing down cancer progression.
- Brand names
- Vargatef
- Other names
- nintedanib esilate + docetaxel
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)LCK (Proto-oncogene tyrosine-protein kinase Lck)TUBB (Tubulin (alpha and beta subunits))FGFR2 (Keratinocyte growth factor receptor)PDGFRB (Platelet-derived growth factor receptor beta)
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