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docetaxel + oxaliplatin + cetuximab

Development stage: Unknown
Lead developer: US Oncology Research
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

A combination chemotherapy regimen containing **docetaxel** (a taxoid that inhibits microtubule depolymerization), **oxaliplatin** (a platinum compound that forms DNA crosslinks and inhibits replication), and **cetuximab** (a monoclonal antibody against epidermal growth factor receptor (EGFR)). This protocol is used investigationally and in clinical trials for advanced **gastric adenocarcinoma** and **gastroesophageal junction adenocarcinoma**. Mechanistically, docetaxel and oxaliplatin act as cytotoxic agents while cetuximab targets EGFR to inhibit tumor cell proliferation and may help overcome resistance to chemotherapy.

Other names: DOCOX+C

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)TUBB (Tubulin (alpha and beta subunits))DNA

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