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docetaxel + plinabulin
- Development stage
- Unknown
- Lead developer
- BeyondSpring
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Docetaxel + plinabulin is a combination therapy under investigation primarily for the treatment of non-small cell lung cancer (NSCLC), particularly in patients with EGFR wild-type tumors who have received prior treatments. Docetaxel is a well-established microtubule-stabilizing chemotherapeutic agent, while plinabulin is a novel, investigational small molecule that acts as an immunomodulating microtubule-destabilizing agent. Plinabulin binds to the colchicine-binding site on β-tubulin, disrupting tumor vasculature and promoting dendritic cell maturation and T-cell activation via GEF-H1 activation. This combination has demonstrated improved overall survival and reduced incidence of severe neutropenia compared to docetaxel alone in Phase 3 clinical trials. The regimen is being developed by BeyondSpring Pharmaceuticals[1][2][3][4][5][6].
- Other names
- plinabulin + docetaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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