Drug intelligence / Profile preview

docosahexaenoic acid + eicosapentaenoic acid + potassium thiocyanate

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination product containing docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and potassium thiocyanate. DHA and EPA are omega-3 polyunsaturated fatty acids commonly found in fish oil, known for their lipid-lowering, anti-inflammatory, and cardioprotective effects. Potassium thiocyanate is a salt that has been historically used as an antihypertensive agent and investigated for its potential to modulate vascular function. In pilot clinical research, this combination was studied in children with sickle cell anemia to assess its effect on cerebral artery blood velocity; results suggested it may help normalize or prevent progression of abnormal blood flow velocities associated with increased stroke risk in this population[1]. The mechanism likely involves the anti-inflammatory properties of omega-3 fatty acids combined with the vasodilatory or modulatory effects of potassium thiocyanate.

02

Targets

PPARA (Peroxisome proliferator-activated receptor alpha)

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