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A fixed-dose combination of three antiretroviral drugs: **dolutegravir**, an integrase strand transfer inhibitor; **lopinavir**, a protease inhibitor; and **ritonavir**, a protease inhibitor primarily used to boost the plasma levels of lopinavir through CYP3A inhibition. All three agents are **small molecules** used in the management of HIV-1 infection, though this specific triple combination is not marketed as a fixed product but may be used together in special clinical circumstances, such as salvage therapy for treatment-experienced patients or situations of resistance/intolerance to standard regimens.
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