domperidone + esomeprazole

Domperidone + esomeprazole is a fixed-dose combination of two pharmaceutical agents used primarily for the treatment of gastroesophageal reflux disease (GERD), acid reflux, and functional dyspepsia. Domperidone is a prokinetic agent that acts as a dopamine D2 receptor antagonist, increasing lower esophageal sphincter pressure and enhancing gastric motility to facilitate gastric emptying. Esomeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme in parietal cells of the stomach. The combination provides both symptomatic relief from acid-related disorders and improved gastrointestinal motility, making it effective for patients with GERD who have inadequate response to PPI monotherapy or who experience associated nausea or bloating. Clinical studies indicate this combination is generally safe and well-tolerated, with adverse events similar to those seen with PPI monotherapy[1][2][5][9].

Brand names

Nexpro RDEsomac DRanidom RDIzra-DLupisoz-DEsogress-DZosa-DRanidom DSomtax-DRanidom O NF

Other names

domperidone + esomeprazole