Drug intelligence / Profile preview

domperidone + rabeprazole

Development stage
Unknown
Lead developer
Fawn
Modality
Small Molecules
Administration
Oral
01

Overview

CANALI (specifically CANALI 40 DSR Capsule) is a fixed-dose combination of rabeprazole sodium and domperidone. Rabeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase pump in parietal cells. Domperidone is a dopamine D2 receptor antagonist with prokinetic and antiemetic properties that enhances gastrointestinal motility and accelerates gastric emptying. This combination is marketed by Fawn Incor and is indicated for the treatment of gastroesophageal reflux disease (GERD), dyspepsia, and other acid-related gastrointestinal disorders associated with motility dysfunction.

Brand names
CANALICANALI 40 DSRCANALI40 DSRCANALI-40 DSRCANALI 40 DSR CapsuleCANALI40 DSR CapsuleCANALI-40 DSR CapsuleCANALI D
Other names
domperidone + rabeprazolerabeprazole + domperidone
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)DRD2 (Dopamine D2 Receptor)

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