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donafenib + lenvatinib + apatinib
- Development stage
- Unknown
- Lead developer
- Suzhou Zelgen Biopharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
donafenib + lenvatinib + apatinib is a combination of three small-molecule multi-kinase inhibitors used in the treatment of hepatocellular carcinoma (HCC). This combination is specifically highlighted in clinical trial contexts (such as NCT05523609) where these agents serve as the targeted therapy component of a multimodal regimen including hepatic arterial infusion chemotherapy (HAIC) and PD-1 inhibitors (e.g., sintilimab, camrelizumab, or tislelizumab). Donafenib, a deuterated sorafenib derivative, targets Raf kinases and VEGFR; lenvatinib targets VEGFR1-3, FGFR1-4, PDGFRα, KIT, and RET; and apatinib (rivoceranib) is a highly selective inhibitor of VEGFR-2. Together, these agents provide comprehensive inhibition of angiogenesis and tumor cell signaling pathways to treat postoperative HCC with microvascular invasion (MVI).
- Brand names
- Zepaton
- Other names
- Rivoceranib
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)FLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)RAF1 (c-Raf-1 (Y340D/Y341D))RET (Rearranged during transfection receptor tyrosine kinase)SRC (Proto-oncogene tyrosine-protein kinase Src)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)BRAF (B-Raf proto-oncogene, serine/threonine kinase)
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