Drug intelligence / Profile preview

donepezil + escitalopram

Development stage: Unknown
Lead developer: Eisai
Modality: Small Molecules
Administration: Oral, Transdermal

Overview

This represents a drug combination with a moderate interaction. Donepezil is an acetylcholinesterase inhibitor used to treat Alzheimer's dementia, while escitalopram is an SSRI antidepressant. When used together, they may increase the risk of QT prolongation (irregular heart rhythm). Additionally, escitalopram's potential anticholinergic effects could theoretically reduce donepezil's effectiveness.

Targets

SERT (Sodium-dependent serotonin transporter)Acetylcholinesterase

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