donepezil + quetiapine

Donepezil + quetiapine is a combination of two pharmaceutical drugs used primarily in the management of behavioral and psychological symptoms in patients with dementia, particularly Alzheimer's disease. Donepezil is an acetylcholinesterase inhibitor that increases acetylcholine levels in the brain by inhibiting its breakdown, thereby improving cognitive function and some behavioral symptoms. Quetiapine is an atypical antipsychotic that acts mainly as an antagonist at serotonin 5-HT2A and dopamine D2 receptors, reducing psychosis, agitation, and other neuropsychiatric symptoms. This combination may be considered for patients with Alzheimer's disease who present with significant behavioral disturbances such as aggression or psychosis[2][4]. However, there are moderate drug interaction risks; co-administration can increase the risk of extrapyramidal side effects (movement disorders) due to increased central cholinergic activity from donepezil combined with dopamine blockade from quetiapine[3][7][9]. The use of this combination should be closely monitored by healthcare professionals.

Other names

donepezil and quetiapinedonepezil plus quetiapine