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donepezil + sertraline

Development stage: Preclinical
Lead developer: Eisai
Modality: Small Molecules
Administration: Oral

Overview

A combination of donepezil, an acetylcholinesterase inhibitor used for Alzheimer's disease, and sertraline, a selective serotonin reuptake inhibitor (SSRI) used for depression and anxiety disorders. This combination has been studied for treating depression with cognitive impairment, showing potential benefits in improving both depression symptoms and cognitive function.

Targets

SERT (Sodium-dependent serotonin transporter)Acetylcholinesterase

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