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donor-derived CD34+ hematopoietic stem cells
- Development stage
- Unknown
- Lead developer
- Columbia University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This investigational cell therapy consists of donor-derived CD34+ hematopoietic stem cells (HSCs) developed by Columbia University for patients undergoing intestinal transplantation. Led by Dr. Megan Sykes at the Columbia Center for Translational Immunology, the approach involves infusing CD34+ cells isolated from the organ donor's bone marrow into the recipient. The primary mechanism is the induction of mixed chimerism—a state where both donor and recipient hematopoietic cells coexist—to promote immune tolerance toward the transplanted intestinal allograft. By establishing this tolerance, the therapy aims to minimize or eliminate the need for long-term systemic immunosuppressive medications, thereby reducing the associated risks of infection and malignancy in adult transplant recipients.
- Other names
- CD34+ stem cellsdonor-derived CD34+ cellshematopoietic stem cells
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