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donor lymphocyte infusion (Peking University People's Hospital)
- Development stage
- Unknown
- Lead developer
- Peking University People's Hospital
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
Donor lymphocyte infusion (DLI) is a cellular immunotherapy protocol developed and utilized by Peking University People's Hospital for the treatment and prevention of relapse in patients with acute leukemia following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The therapy involves the infusion of lymphocytes, primarily T cells, collected from the original stem cell donor. These donor cells recognize and eliminate residual recipient leukemia cells through the graft-versus-leukemia (GVL) effect. In the specific clinical context of Peking University People's Hospital, DLI is often administered in a modified, MRD-guided (minimal residual disease) fashion and may be combined with consolidation chemotherapy to enhance efficacy while monitoring for graft-versus-host disease (GVHD) status.
- Other names
- DLIdonor leukocyte infusion
02
Targets
MiHA (Minor histocompatibility antigen)pMHC (Peptide-MHC complex family)
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