double antibiotic paste + chitosan

Double antibiotic paste + chitosan is a combination formulation used primarily in regenerative endodontics and dental pulp therapy. The "double antibiotic paste" (DAP) typically consists of metronidazole and ciprofloxacin, omitting minocycline to avoid tooth discoloration. Chitosan is a natural polycationic polymer derived from chitin, known for its biocompatibility, broad-spectrum antibacterial and antifungal properties, biodegradability, and ability to act as a drug delivery vehicle. When combined with DAP in hydrogels or scaffolds (such as double antibiotic-loaded chitosan hydrogel), this formulation enhances the antimicrobial effect against pathogens like Enterococcus faecalis and Candida albicans while supporting cell viability and mineralization activity of dental pulp stem cells. Chitosan's slow-release properties improve the bioavailability of antibiotics while reducing toxicity[1][2][3][4]. This combination is under investigation for use as an intracanal medicament in root canal disinfection—especially for immature permanent teeth—and has shown superior outcomes compared to other carriers such as platelet-rich fibrin[4].

Other names

DAP + chitosandouble antibiotic-loaded chitosan hydrogelDAPF with chitosan