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dovitinib + fulvestrant
- Development stage
- Unknown
- Lead developer
- Allarity Therapeutics
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
Dovitinib + fulvestrant is a combination therapy that pairs dovitinib, a potent inhibitor of fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR), and platelet-derived growth factor receptor (PDGFR), with fulvestrant, a selective estrogen receptor antagonist. This combination was investigated for treating hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer that had progressed during or after prior endocrine therapy. The combination showed promising clinical activity specifically in patients with FGF pathway amplification, with a median progression-free survival of 10.9 months versus 5.5 months in the placebo arm for this subgroup.
- Other names
- Dovitinib combined with fulvestrantDovitinib plus fulvestrant
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)ESR2 (ERβ)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR3 (Fibroblast growth factor receptor 3)ESR1 (ERα)VEGFR-1 (Vascular endothelial growth factor receptor 1)FGFR1 (Fibroblast growth factor receptor 1)
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