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doxorubicin (PhotoDOX formulation)
- Development stage
- Unknown
- Lead developer
- POP Biotechnologies
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
PhotoDOX is a novel, light-activated drug delivery system for cancer therapy that combines the chemotherapeutic agent doxorubicin with proprietary photosensitive porphyrin-phospholipid (PoP) nanoparticles. Developed by POP Biotechnologies, PhotoDOX enables localized and controlled release of doxorubicin at tumor sites upon activation by light. This approach enhances therapeutic efficacy and minimizes systemic toxicity compared to conventional chemotherapy or photodynamic therapy. The PoP-liposome formulation provides long circulation time, robust serum stability, and photodynamic enhancement of vascular permeability, allowing precise targeting of solid tumors that are resistant to standard treatments[1][2][3].
- Brand names
- PhotoDOX
- Other names
- PhotoDOX CPT CM BreastPhotoDOX-CPT
02
Targets
TOP2B (DNA topoisomerase II beta)DNATOP2A (DNA topoisomerase II)
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