doxorubicin + enalapril

This combination involves **doxorubicin**, an anthracycline antibiotic used primarily as a chemotherapeutic agent, and **enalapril**, an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. The combination is studied for its potential to mitigate doxorubicin-induced cardiotoxicity. Doxorubicin works by intercalating DNA strands, thereby inhibiting the synthesis of macromolecules and inducing apoptosis in cancer cells. Enalapril reduces the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby lowering blood pressure and reducing strain on the heart.