Drug intelligence / Profile preview

doxorubicin + fluorouracil + cisplatin

Development stage
Unknown
Lead developer
Farmitalia
Modality
Small Molecules
Administration
Intravenous
01

Overview

Doxorubicin + fluorouracil + cisplatin is a chemotherapy combination regimen used to treat various cancers, particularly gastrointestinal malignancies. This combination has been studied in gastric cancer, pancreatic cancer, and other upper gastrointestinal carcinomas. The regimen typically consists of cisplatin administered intravenously on day 1, doxorubicin administered intravenously on days 1 and 2, and 5-fluorouracil administered intravenously on day 2. In some protocols, vincristine may be added to this combination (C5VD). The combination shows promising efficacy but can cause toxicities including leukopenia, stomatitis, diarrhea, nausea, vomiting, and alopecia.

Other names
FAPC5VDC-5VDC 5VD
02

Targets

TOP2A (DNA topoisomerase II)TS (Thymidylate synthase)DNA

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