doxorubicin + fluorouracil + vinorelbine

This is a combination chemotherapy regimen consisting of doxorubicin, fluorouracil (5-FU), and vinorelbine. All three are small molecule cytotoxic agents with distinct mechanisms of action. Doxorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II, leading to DNA damage and cell death. Fluorouracil is an antimetabolite that inhibits thymidylate synthase, disrupting DNA synthesis and repair. Vinorelbine is a vinca alkaloid that disrupts microtubule formation during mitosis, inhibiting cell division. This combination has been studied primarily in advanced or metastatic breast cancer as first-line therapy[1][5]. The regimen may be referred to as the FAN or SUPERFAN protocol depending on the inclusion of folinic acid[5].

Other names

FAN regimenSUPERFAN regimen